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About SPRAVATO® (esketamine) Treatment

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth, to treat:

  • Adults with treatment-resistant depression (TRD)

  • Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions

How does SPRAVATO®Work?

SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants. The exact way that SPRAVATO® works is unknown.

HOW OFTEN WILL I RECEIVE TREATMENT?

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ADULTS WITH TREATMENT-RESISTANT DEPRESSION (TRD)

WEEKS 1-4

Twice weekly

WEEKS 5-8

Once weekly

WEEKS 5-8

Once every

week or two

DEPRESSIVE SYMPTOMS IN ADULTS WITH MAJOR DEPRESSIVE DISORDER

FOUR WEEKS

Twice weekly

Depending on which treatment you receive, you and your healthcare provider will determine if continued treatment with SPRAVATO® is necessary.

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What to Expect During your 
SPRAVATO®  Treatment

  • You will not be able to drive, so plan transportation for treatment days. 

  • You will administer the nasal spray yourself under the supervision of a healthcare provider.

  • You'll be monitored for side effects for at least two hours.

  • Your healthcare provider will tell you when it's OK to leave.

  • Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.

 SPRAVATO®  Testimonial:
Allison's Story

Allison's son tried many oral antidepressants without relief.  Now, because of  SPRAVATO®, Allison's son is starting to feel like himself again.

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